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Gestational diabete 高危險妊娠~妊娠性糖尿病

2016-11-10
Gestational diabetes (or gestational diabetes mellitus, GDM) 
When a woman is not diagnosed of diabetes but exhibits high blood pressure level during pregnancy, it is often the condition of gestational diabetes. 
  1. Classification
    Pre-gestational Diabetes either type I o r type II
    Gestational diabetes: diabetes that develops during pregnancy
  2. Complications of Diabetes in pregnancy
    Maternal
    (1) Polyhydroamnios: from fetal polyuria
    (2) Nephropathy: common in pregestational diabetes, increasing the risk of preeclampsia
    (3) Retinopathy: occurs after several years of pregestational diabetes, often deteriorates during pregnancy
    (4) Diabetes ketoacidosis: May occur at lower glucose concentration
    Fetus
    (1) Fetal demise: increased spontaneous miscarrage and fetal death in utero
    (2) Respiratory distress syndrome
    (3) Macrosomia(>4000-4500 g)
    (4) Fetal hypoglycemia
    (5) Hyperbilirubinemia
    (6) Polycythemia
    (7) Hypocalcemia
  3. Screening glucose challenge test
    All patient screened between 24 and 28 weeks. 
    With 75gm high concentration sugar water and keep fasting before test 4-6 hours.
    2 hours(75gm) Oral glucose tolerance test
    Time National Diabetes Data Group(mg/dl)
    fasting 92
    1 180
    2 153
  4.  Intra-partum management
    Nutritional counseling differs individually and it varies with patients’ weight and height. 
    fasting glucose levels should be under 105 mg/dl. or 2-hr post-meal sugar level should be under 120mg/dl, if not, pharmacologic treatment was suggested(insulin administration)
    Fetal evaluation
    (1) fetal activity assessment, NST(non-stress test: a 20-minutes-test of fetal movement and fetal heart beat relation) beginning at 32-34 wks
    (2) Ultrasound : first time at 18-20 weeks, and the second time is at 30-32 weeks
    a. Insulin treatment: It is usually recommended that oral hypoglycemic agents be discontinued once pregnancy is diagnosed 
    b. Exercises like swimming and bicycle riding are highly recommended; however, riding bicycles is inappropriate toward the last stage of the pregnancy, simple walk is recommended. 
  5. During labor care
    Maintain euglycemia(normal sugar level) during labor
    Sugar control with Insulin drip and check sugar every hour in labor
  6. Postpartum management
    Home glucose monitoring 
    Diet instruction
    Prevention of hemorrhage and infection
    Regular postpartum blood sugar trace, and sugar test within 6 wks of delivery
    Breastfeeding encouraged 
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